Study on Optimizing High-Gradient Magnetic Separation—Part 1: Improvement of Magnetic Particle Retention Based on CFD Simulations
Study on Optimizing High-Gradient Magnetic Separation—Part 1: Improvement of Magnetic Particle Retention Based on CFD Simulations作者机构：Trier University of Applied Sciences Environmental Campus Birkenfeld Institute for Biotechnical Process Design Birkenfeld Germany
出 版 物：《World Journal of Condensed Matter Physics》 (凝固态物理国际期刊（英文）)
年 卷 期：2016年第6卷第2期
页 面：123-136页
学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学]
主 题：Computational Fluid Dynamics Finite Element Method Magnetic Particles High-Gradient Magnetic Separator Magnetic Filtration Biocatalysis Enzyme Purification
摘 要：The introduction of functionalized magnetizable particles for the purification of enzymes or for the multi-use of pre-immobilized biocatalysts offers a great potential for time and cost savings in biotechnological process design. The selective separation of the magnetizable particles is performed for example by a high-gradient magnetic separator. In this study FEM and CFD simulations of the magnetic field and the fluid flow field within a filter chamber of a magnetic separator were carried out, to find an optimal separator design. The motion of virtual magnetizable particles was calculated with a one-way coupled Lagrangian approach in order to test many geometric and parametric variations in reduced time. It was found that a flow homogenisator smoothed the fluid flow, so that the linear velocity became nearly equal over the cross section in the direction of flow. Furthermore the retention of magnetizable particles increases with a high total edge length within the filter matrix.
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