Maximizing of Asymptomatic Stage of Fast Progressive HIV Infected Patient Using Embedding Method

作     者：Hassan Zarei Ali Vahidian Kamyad Sohrab Effati 

作者机构：不详 

出 版 物：《Intelligent Control and Automation》 (智能控制与自动化（英文）)

年 卷 期：2010年第1卷第1期

页      面：48-58页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：HIV Model Optimal Control Measure Theory Linear Programming 

摘      要：A system of ordinary differential equations, which describe various aspects of the interaction of HIV with healthy cells in fast progressive patient, is utilized, and an optimal control problem is constructed to prolong survival and delay the progression to AIDS as far as possible, subject to drug costs. Optimal control problem is approximated by linear programming model using measure theoretical approach and suboptimal combinations of reverse transcriptase inhibitor (RTI) and protease inhibitor (PI) drug efficacies are proposed. The Comparison of healthy CD4+ Tcells counts, virus particles and immune response, before and after the treatment is introduced.