A Study of the Effect of <i>Citrus aurantium</i>L. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice

作     者：Maryam Khosravi Shahrzad Khakpour Leila Adibi Mahsa Hadipour Jahromy 

作者机构：Biology Department Faculty of Biological Sciences Islamic Azad University North Tehran Branch Tehran Iran Faculty of Medicine Medical Sciences Research Center Tehran Medical Branch Islamic Azad UniversityTehran Iran 

出 版 物：《Journal of Behavioral and Brain Science》 (行为与脑科学期刊（英文）)

年 卷 期：2014年第4卷第10期

页      面：470-476页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Anxiety Mice Citrus aurantium L. Diazepam 

摘      要：Anxiety is among the most common disorders affecting a great number of people. Different neurotransmitter systems, such as GABAergic system, play an important role in emergence of anxiety-related behaviors. In this study, we have investigated the effect of Citrus aurantium L. essential oil on anxiety and its interaction with GABAergic pathways. Male mice were assigned into control, sham, and experimental groups. Intraperitoneal injection of Citrus aurantium L. essential oil was applied at doses of 0.5, 2.5, and 5 percent for 5 days. Diazepam (0.1 mg/kg) was injected on the fifth day, thirty minutes before applying Citrus aurantium L. essential oil. The anxiety-related behavior of mice was then assessed using elevated plus-maze test. In groups receiving Citrus aurantium L. essential oil at doses of 2.5 and 5 percent, the percent time spent in the open arms increased significantly (P Citrus aurantium L. essential oil resulted in increasing in the number of entries to the open arms and the percent time spent in the open arms (P Citrus aurantium L. essential oil can reduce anxiety-related behaviors in male mice thah may act via GABAergic system.