A Numerical Study to Precise the Estimation of the “Good” Mound Height in Endoscopic Treatment of VUR

作     者：Mehdi Shirazi Zahra Jahanabadi Zeinab Hooshyar Zahra Mortazavinia Alireza Mehdizadeh Mojtaba Taherisadr 

作者机构：Urology Department Shiraz University of Medical Science Shiraz Iran Mechanical Engineering Shiraz University Shiraz Iran école Polytechnique de Montréal Mechanical Engineering Department Montreal Canada Shiraz University of Medical Science (SUMS) Shiraz Iran Biomedical Engineering Department Isfahan University Esfahan Iran 

出 版 物：《Journal of Biomedical Science and Engineering》 (生物医学工程（英文）)

年 卷 期：2014年第7卷第11期

页      面：941-947页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Mound Height Endoscopic Treatment Vesico Ureteral Reflux Numerical Simulation 

摘      要：Objective: To ascertain the technique and volume of injection increasing the success rate of endoscopic VUR treatment, we develop a novel method to numerically describe the relationship between intramural ureter anatomy, intravesical pressure, and the theoretical mound height needed for adequate treatment. Methods: The main purpose of this study is to construct a finite element simulation of intramural ureter and injected mound which aims to numerically define the relationship between indexes which have influence in VUR endoscopic treatment. Using linearization software and numerically simulation data, the relationship between effective indexes has been derived. Results: By linearization of the effective parameters of different finite element models, the relationship between effective parameters in filling phase is derived as: H (m) = ﹣0.003467 (m) + 0.7864D (m) + 0.000233. This equation depicts adequate injected mound height as a function of internal diameter and intramural length, H = f(L, D). Conclusion: Using numerical simulation, we introduced the novel formula to predict the height of injected mound in endoscopic VUR treatment. As a result of this study, in order to increasing the success rate of this treatment, the ratio of mound height to intramural ureter diameter should be approximately 78%.