The Action of Chronic Nicotine on the Effects of Ethanol on Anxiety, Locomotion and Metabolism and the Feeding and Drinking Behaviors of Rats
The Action of Chronic Nicotine on the Effects of Ethanol on Anxiety, Locomotion and Metabolism and the Feeding and Drinking Behaviors of Rats作者机构：P.K. Anokhin Research Institute of Normal Physiology Moscow Russia
出 版 物：《Pharmacology & Pharmacy》 (药理与制药（英文）)
年 卷 期：2014年第5卷第11期
页 面：1077-1084页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Nicotine Ethanol Metabolism Drinking Behavior Locomotion
摘 要：The objective of these experiments was to study the effects of ethanol on the anxiety level, activity, metabolic rate, and feeding and drinking behaviors of rats that were chronically treated with nicotine. The chronic intake of nicotine changed the effects of the acute administration of ethanol. Thus, the nicotine-dependent rats demonstrated a significantly decreased anxiolytic-like effect in response to ethanol than did the control rats. This decrease may lead to a decrease in the sensitivity of animals to the positive reinforcing effects of ethanol and an increase in their consumption to achieve the desired effect. The negative action of ethanol on the metabolism, motor activity and drinking behavior of rats that chronically consumed nicotine was increased. Chronic nicotine intake can be assumed to lead to cross-tolerance of the effects of ethanol. On the contrary, the sensitivity to the action of ethanol increased.
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