Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model
Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model作者机构：Departamento de Fisiología Facultad de Medicina UNAM México D.F. México
出 版 物：《Advances in Aging Research》 (老年问题研究（英文）)
年 卷 期：2014年第3卷第4期
页 面：318-325页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Rat Melatonin Hippocampus Antioxidant Aging
摘 要：Melatonin is a hormone synthesized and released primarily by the pineal gland. Its secretion fol-lows a circadian rhythm with a peak overnight. Its secretion is initiated approximately to the three months of age and continues to rise during the childhood. Previous to the puberty there is a de-crease of melatonin secretion that continues until the old age. Melatonin has effects in the body and acts through at least four mechanisms: membrane receptors, orphan nuclear receptors, calmodulin and free radicals. It has been suggested that aging can be a consequence of the oxidation of cells that eventually become vulnerable to injury and die. This work reviews the antioxidant effects of melatonin in a rodent model, on the formation of free radicals, on the MAP2 protein expression and on the electrophysiology of the hippocampus at different ages. The results indicate that melatonin maintains in a “best state to the experimental animals compared to controls. It suggests the use of melatonin as a therapy to prevent or delay the aging effects on the cells.
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