Broad-Spectrum Antibacterial Characteristics of Four Novel Borate-Based Bioactive Glasses
Broad-Spectrum Antibacterial Characteristics of Four Novel Borate-Based Bioactive Glasses作者机构：Departmentof Biological Sciences Missouri University of Science and Technology Rolla MO USA Department of Materials Science and Engineering Missouri University of Science and Technology Rolla MO USA
出 版 物：《Advances in Microbiology》 (微生物学（英文）)
年 卷 期：2016年第6卷第10期
页 面：776-787页
学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术]
主 题：Bioactive Glass Antibacterial Properties Metal Ions
摘 要：Bioactive glasses have been developed for medical applications in the body for bone and tissue repair and regeneration. We have developed a borate-containing bioactive glass (13-93B3, referred to as B3), which is undergoing clinical trials to assess its wound-healing properties. To complement the healing properties of B3, metal ion dopants have been added to enhance its antimicrobial properties. Bioactive glasses doped with silver, gallium or iodine ions were found to have broad spectrum antimicrobial effects on clinically relevant bacteria including MRSA. While the B3 glass alone was sufficient to produce antibacterial effects on select bacteria, adding dopants enhanced the broad-spectrum antibacterial properties: Live-Dead staining fluorescence microscopy suggests cell membrane integrity is disrupted in gram positive bacteria exposed to the glass compounds, but not gram negative bacteria, indicating multiple mechanisms of action for each glass formulation.
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