Intraflagellar Protein 88 Interactome Analysis:A Bioinformatics Approach Highlights Its Role in Testis and Sperm Function

作     者：Maria Joao Freitas Margarida Fardilha 

作者机构：Signal Transduction LaboratoryCentre for Cell BiologyHealth Sciences Department and Biology DepartmentUniversity of AveiroAveiroPortugal 

出 版 物：《Journal of Biophysical Chemistry》 (生物物理化学（英文）)

年 卷 期：2014年第5卷第3期

页      面：99-106页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Intraflagellar Protein 88 Homolog Spermatozoa Network 

摘      要：Intraflagellar transport (IFT) is essential for cilium and flagellar assembly. This movement is accomplished by two IFT complexes: A and B. IFT88, intraflagellar protein 88, is a core element of IFT complex B. This protein has been linked to migration, to olfactory function, spindle formation and to mitosis. Recently, IFT88 was identified as a TCTEX1D4 interacting protein in human testis, suggesting a role in male reproduction. To broaden the knowledge on IFT88 function, particularly in testis and spermatozoa, an in silico analysis of IFT88 and IFT88 interactome was undertaken. IFT88 appears to be prone to protein-protein interactions, involved in spermatogenesis and since it interacts with key proteins related to male fertility, it may have a role in reproduction.