The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia

作     者：Clare M. Crean Ken I. Mills Kienan I. Savage 

作者机构：Centre for Cancer Research and Cell Biology (CCRCB) Queen’s University Belfast Belfast UK 

出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)

年 卷 期：2017年第8卷第8期

页      面：691-698页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：DNA Repair Acute Myeloid Leukemia 

摘      要：Acute myeloid leukemia (AML) is a clonal heterogeneous disease of the myeloid white blood cells. It is characterised by an accumulation of immature blast cells and a number of chromosomal and genetic mutations have been identified. In both de novo and therapy-related AML, defective DNA repair mechanisms are responsible for some of these genetic abnormalities. Targeting the DNA repair mechanism has been shown to be successful against certain forms of solid tumors and may represent a novel therapeutic approach for AML.