Clinicopathologic Characteristics and Prognosis Analysis of Marjolin's Ulcer in 40 Cases
作者机构：Department of Plastic SurgeryDepartment of DermatologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of AnesthesiologyJining No.1People's Hospital Jining 272000China The Ninth Department of Plastic SurgeryPlastic Surgery HospitalChinese Academy of Medical SciencesBeijing100144 China 不详
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2018年第38卷第6期
页 面：1038-1044页
核心收录：
学科分类：10[医学]
主 题：Marjolin's ulcer clinicopathological pattern prognosis
摘 要：Marjolin s ulcer (MU)is a rare but aggressive epidermoid carcinoma observed in scars or *** article provides comprehensive characteristics and prognostic details of MU. Clinical data of 40patients with MU between January 2010 and December 2017 were analyzed *** cell carcinoma was the most common pathological type (35/40,87.5%). Extended resection was performed to treat all cases with skin grafting or flap ***-up duration ranged from 6 to 96 months (median,52 months)and recurrence was noted in 9 *** 1-,3-and 5-year recurrence-free survival (RFS)rates were 87.2%,87.2%,83.2%respectively and the recurrence rate was 22.5%.Univariate analysis revealed that cause of scars (P=0.044),lesion appearance (P=0.036),ultraviolet radiation exposure (P=0.000),depth (P=0.001)and histological grade (P=0.027)had a statistically significant correlation with prognosis of *** analysis revealed that depth (P=0.034,RR=2,681,95%CI:1.077-6.674)and histological grade (P=0.008,RR=2.820,95%CI:1.3156.050)were independent prognostic factors for *** conclusion,superficial infiltration and high-grade differentiation predict more favorable prognosis. Careful follow-up of high-risk groups is strongly recommended to prevent recurrence and improve prognosis.
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