JAK-STAT pathway in carcinogenesis:Is it relevant to cholangiocarcinoma progression?

作     者：Olga V Smirnova Tatiana Yu Ostroukhova Roman L Bogorad 

作者机构：Laboratory of Endocrinology Biological Faculty M.V. Lomonosov Moscow State University Inserm U845 Paris France Université Paris Descartes Faculté de Médecine René Descartes Centre de Recherche Croissance et Signalisation Equipe PRL GH and tumours Site Necker Paris F-75015 France 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第48期

页      面：6478-6491页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cholangiocarcinoma Janus tyrosine Kinases Signal Transducers and Activators of Transcription Prolactin Interleukin-6 Cytokine receptors Receptor tyrosine kinases 

摘      要：The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development.