Enhancement strategies of targetability, response and photostability for in vivo bioimaging

作     者：Kaizhi Gu Wei-Hong Zhu Xiaojun Peng 

作者机构：Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine Chemicals Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterSchool of Chemistry and Molecular Engineering East China University of Science & Technology State Key Laboratory of Fine Chemicals Dalian University of Technology 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2019年第62卷第2期

页      面：189-198页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：supported by National Natural Science Foundation of China for Science Center Program (21788102) National Key Research and Development Program (2016YFA0200300) Natural Science Foundation of China (21636002) National Postdoctoral Program for Innovative Talents (BX201700075) 

主　　题：fluorescent probe bioimaging targetability response rate photostability 

摘      要：Analyses of the physiology and pathology of active biochemical species in their native contexts are critical for early diagnosis and therapy. Optical imaging has emerged as one of the promising modalities for noninvasive and real-time visualization of important biomolecules or biological events, and it has witnessed major advances in the field of imaging in vitro and in vivo. In this review, we present a survey of common approaches and tactics for enhanced targetability, response rate, and photostability in bioimaging applications. Recently developed and representative examples are illustrated on the cellular and tissue levels.