Synthesis of 1,2-phenylenedimethanols by base-promoted reduction of isobenzofuran-1(3H)-ones with silane
Synthesis of 1,2-phenylenedimethanols by base-promoted reduction of isobenzofuran-1(3H)-ones with silane作者机构：Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University Technology Research Insititute of Shanghai Huayi (Group) Company
出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)
年 卷 期：2019年第30卷第3期
页 面：725-728页
核心收录：
基 金：the National Natural Science Foundation of China (Nos. 21572034 21732007 21871054) for financial support
主 题：Isobenzofuran-1(3H)-one 1,2-Phenylenedimethanol Reductive transformation Ring-opening reaction Silane
摘 要：An efficient method for preparation of substituted 1,2-phenylenedimethanols and aliphatic 1,4-diols that are valuable intermediates in organic synthesis, has been developed by the base-promoted reduction of isobenzofuran-1(3H)-ones and y-lactones with silane under mild conditions. Compared with traditional procedures using stoichiometric amounts of metal hydrides and alkyl reductants, the present method avoids the use of sensitive reagents and is operationally simple and a broad variety of functional groups are tolerated.
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