TNF related apoptosis-inducing ligand and its receptors in ocular tumors

作     者：Qian Ning, Xin-Han Zhao 

作者机构：Department of Oncology the First hospital Affiliated to School of Medicine of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Outpatient Department of Oncology Cancer Institute Fourth Military Medical University Xi'an 710032 Shaanxi Province China 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2011年第4卷第5期

页      面：552-557页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：tumor necrosis factor related apoptosis-inducing ligand ocular tumors apoptosis 

摘      要：Most of the ocular tumors have poor prognosis, and they remain a difficult problem in the area of ophthalmology. With the rapid development of molecular biology and immunologic techniques and the deep research on ocular tumor related genes, it becomes possible to diagnose and treat malignant tumors from the molecular level. The tumor necrosis factor related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor (TNF) super family, is a promising candidate, either alone or in combination with established cancer therapies, since it can initiate apoptosis through the activation of their death receptors. The ability of TRAIL to selectively induce apoptosis of transformed, virus-infected or tumor cells but not normal cells promotes the development of TRAIL-based cancer therapy. Here, we will review TRAIL and its receptors structure, function, mechanism of action and application in ocular tumors therapy.