Chelerythrine chloride binding of guanosine in aqueous solution

作     者：Fan Liu Jian Bin Zhang Zheng Fu Zhang Xiao Yan Zhang Zuo Peng Du Xiong Hui Wei 

作者机构：College of Chemical Engineering Inner Mongolia University of Technology Huhhot 010051 China Department of Applied Chemistry College of Chemistry & Molecular Engineering Peking University Beijing 100190 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2009年第20卷第1期

页      面：66-70页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 10[医学] 

基　　金：This project is financed by Jiangxi Boyuan Industry Co. Ltd.(Jiangxi province China) 

主　　题：Chelerythrine (CHE) Guanosine UV-vis spectra Fluorescence spectra 

摘      要：In this work, the interaction between chelerythrine （CHE） and guanosine is studied using UV-vis and fluorescence measurements at various temperatures. The UV-vis spectra show that the increasing guanosine concentrations result in the decreasing absorption intensity and red shift of CHE E absorption band （267 nm）. The fluorescence spectra are fitted to linear analysis, yielding a binding constant of 1.04×10^4 L/tool at 298.15 K of CHE with guanosine. Besides, with △rHm^θ = - 8.26 kJ/mol, △rGm^θ = -22.90 kJ/mol, and △rSm^θ = 49.38 J/（mol K） the interaction should be entropy-driven and exterothermic.