Cell Death Mechanisms Induced by Cytotoxic Lymphocytes

作     者：Chávez-Galán L Arenas-Del Angel MC Zenteno E Chávez R Lascurain R 

作者机构：Departamento de BioquímicaInstituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas" Departamento de BioquímicaFacultad de MedicinaUniversidad Nacional Autónoma de México 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2009年第6卷第1期

页      面：15-25页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主　　题：apoptosis cytotoxic cell granule-dependent exocytosis FasL TNF 

摘      要：One of the functions of the immune system is to recognize and destroy abnormal or infected cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is a highly organized multifactor process. Here, we reviewed the apoptosis pathways induced by the two main cytotoxic lymphocyte subsets, natural killer （NK） cells and CD8^＋T cells. In base to recent experimental evidence, we reviewed NK receptors involved in recognition of target-cell, as well as lytic molecules such as perforin, granzymes-A and -B, and granulysin. In addition, we reviewed the Fas-FasL intercellular linkage mediated pathway, and briefly the cross-linking of tumor necrosis factor （TNF） and TNF receptor pathway. We discussed three models of possible molecular interaction between lytic molecules from effector cytotoxic cells and target-cell membrane to induction of apoptosis. Cellular ＆ Molecular Immunology.