Oncolytic adenoviruses:A thorny path to glioma cure

作     者：I.V.Ulasov A.V.Borovjagin B.A.Schroeder A.Y.Baryshnikov 

作者机构：Swedish Medical CenterCenter for Advanced Brain Tumor Treatment55017th AvenueJames TowerSuite 570SeattleWA 98122USA Institute of Oral Health ResearchUniversity of Alabama at Birmingham School of Dentistry19197th Ave SouthBirminghamAL35294USA Michigan State University College of MedicineGrand RapidsMI49503USA Institute of Experimental Diagnostic and BiotherapyN.N.Blokhin Cancer Research Center(RONC)Moscow 115478Russia 不详 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2014年第1卷第2期

页      面：214-226页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported in part by National Cancer Institute(Bethesda,MD)grants R01 NS070289(I.U.,Charles Cobbs-PI),5R03DE021758(A.B.) generous support from Russian Fund of Fundamental Research(#No 11411.0008700.13.082 and No 13411.1008799.13.120(A.Y.B.) 

主　　题：Adenovirus Brain tumor Glioma Self-replicated vector Stem cells 

摘      要：Glioblastoma Multiforme(GBM)is a rapidly progressing brain *** the relatively low percentage of cancer patients with glioma diagnoses,recent statistics indicate that the number of glioma patients may have increased over the past *** therapeutic options for glioma patients include tumor resection,chemotherapy,and concomitant radiation therapy with an average survival of approximately 16 *** rapid progression of gliomas has spurred the development of novel treatment options,such as cancer gene therapy and oncolytic *** testing of oncolytic adenoviruses using glioma models revealed both positive and negative sides of the virotherapy *** we present a detailed overview of the glioma virotherapy field and discuss auxiliary therapeutic strategies with the potential for augmenting clinical efficacy of GBM virotherapy treatment.