TPX2 promotes migration and invasion of human breast cancer cells
TPX2 promotes migration and invasion of human breast cancer cells作者机构：Department of Breast and Thyroid SurgeryWuhan No.1 Hospital Department of Head and Neck SurgeryThyroid and Neck OncologyTianjin Medical University Cancer Institute and Hospital Department of Breast and Thyroid SurgeryUnion Hospital Affiliated To Huazhong University of Science and Technology
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2015年第8卷第12期
页 面：1033-1037页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Science Foundation(81502322)
主 题：Breast cancer TPX2 Proliferation Migration Invasio
摘 要：Objective:To investigate the expression of targeting protein for Xenopus kinesin-like protein 2(TPX2) in breast cancer tissue and to explore its role in proliferation,migration and invasion of breast cancer ***:The mRNA and protein expressions of TPX2 in breast cancer tissue and cell lines were assessed by quantitative RT-PCR and Western *** effect of TPX2 with RNA interference on proliferation,invasion and migration of breast cancer cells was observed by MTT and Transwell ***:Both mRNA and protein expressions of TPX2 were upregulated in breast cancer tissues compared to tumor-adjacent ***2 expression was also upregulated in breast cancer cell lines,and the TPX2 interfered by small interfering RNA could inhibit the proliferation,invasion and migration of breast cancer cells by inhibiting matrix metalloproteinase-2 and matrix ***:Significantly upregulated TPX2 expression is observed in breast cancer tissue and cells,and contributes to promote the proliferation,migration and invasion of breast cancer cells.
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