自身免疫性肝炎患者对硫唑嘌呤的耐受不良与硫代嘌呤甲基转移酶缺乏有关

作     者：Czaja A.J. Carpenter H.A. 陈瑜 

作者机构：Mayo Clinic200 First Street S.W.RochesterMN 55905United States Dr 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2006年第2卷第12期

页      面：5-5页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：自身免疫性肝炎 硫唑嘌呤 甲基转移酶 酶水平 酶缺乏 酶活性 

摘      要：Thiopurine methyltransferase deficiency has been associated with intolerance to *** goals were to assess the frequency of enzyme deficiency in autoimmune hepatitis and correlate deficiency states with azathioprine ***-six patients receiving azathioprine(50-150 mg daily) were evaluated for enzyme activity and azathioprine-related *** findings were compared to 89 similarly treated but untested *** patients(15%) had low thiopurine methyltransferase levels(11.4± 0.9 U/ml RBC;range,3.5-14.9 U/ml RBC) .Azathioprine intolerance occurred as commonly in patients with normal or above normal enzyme levels as in patients with below normal levels(12% versus 15%,p = 0.7) .Patients treated without enzyme testing had the same frequency of complications(9% versus 13%,p = 0.5) as tested *** conclude that routine screening of blood thiopurine methyltransferase levels has a low yield for identifying individual patients at risk for azathioprine toxicity during conventional low dose therapy for autoimmune hepatitis.