Simulation of vessel tissue remodeling with residual stress:an application to in-stent restenosis
作者机构：Department of Mechanical Aerospace and Nuclear EngineeringRensselaer Polytechnic InstituteTroyNYUSA
出 版 物：《International Journal of Smart and Nano Materials》 (国际智能和纳米材料杂志（英文）)
年 卷 期：2019年第10卷第1期
页 面：11-27,I0002页
核心收录：
学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学]
基 金：This work was supported by the Foundation for the National Institutes of Health[NIH-2R01DC005642-10A1] National Natural Science Foundation of China
主 题：Residual stress remodeling growth model in-stent restenosis
摘 要：We present a numerical procedure to model the artery wall remodeling stimulated by stenting considering varying degree of residual *** framework sets up biological remodeling with the existence of residual *** studies suggest that the residual stress originates from the growth and remodeling of the premature ***,it is known that tissue remodeling can happen under mechanical ***,none of the existing research studies the impact of residual stress on the mechanical-driven growth of *** fill this gap,we build a numerical framework that couples the residual stress with a growth model,and examine its impact on tissue *** proposed approach is applied to in-stent restenosis,where the tissue remodeling process is modeled with finite element method,and the residual stress is generated geometrically using open angle *** result shows that residual stress reverses the radial distribution of stress concentration,which is ameliorated by tissue *** thickening of vessel wall tends to increase with residual stress,which links to more severe in-stent *** results demonstrate the important interplay between residual stress and tissue *** findings suggest that residual stress should be considered in the future simulation of tissue remodeling.
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