SH2-B beta upregulates the expression of interleukin-1 beta in lung and visceral primary afferent neurons in asthmatic mice

作     者：Jinping Qi Xiaojie Wang Yun Jin 

作者机构：Department of Anatomy Shenyang Medical College Shenyang 110034 Liaoning Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第34期

页      面：2703-2707页

核心收录：

学科分类：0710[理学-生物学] 090601[农学-基础兽医学] 07[理学] 09[农学] 0906[农学-兽医学] 071006[理学-神经生物学] 

基　　金：grant from the Liaoning Provincial Education Bureau  No. 20060890 

主　　题：SH2-Bβ interleukin-1β asthma primary afferent neurons spinal ganglia afferent nerve pathway 

摘      要：A previous study by our research group showed that nerve growth factor is involved in the onset of asthma through regulating SH2-Bβ expression in the lung and visceral primary afferent neurons of asthmatic mice. This study sought to assess the expression level of interleukin-1β in primary afferent neurons in C7-T5 spinal ganglia, spinal cord and lung in asthmatic mice after blockage of SH2-Bβ. The levels of interleukin-1β protein in primary afferent neurons in the C7-T5 spinal ganglia and lung were decreased, and interleukin-1β mRNA expression also down-regulated in the spinal cord, medulla oblongata and lung tissue after blockage of SH2-Bβ. Our findings indicate that SH2-Bβ can upregulate the expression of interleukin-1β in C7-T5 spinal ganglia, spinal cord and lung of asthmatic mice.