Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives

作     者：Sheng Biao Wan Zhe Lin Liu Di Chen Qing Ping Dou Tao Jiang 

作者机构：Key Laboratory of Marine Drug Ministry of Education Medical College Ocean University of China Qingdao 266003 China The Prevention Program Barbara Ann -Karmanos Cancer lnstitute-and Department.of Pathology Sch~9ol of Medicine Wayne State University Detroit MI USA 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第10期

页      面：1179-1181页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：National Key Research and Development Program of China  NKRDPC  (2003CB71640) 

主　　题：Cryptolepine Trioligomer Synthesis Proteasome 

摘      要：11-Oxo-10,11-dihydroxy-SH-indolo[3,2,b]quinoline7-carboxylic acid was obtained specifically by polyphosphorous acid catalyzed cyclization with optimal reaction conditions. Biological assays showed that it potentially inhibits the proteasomal chymotrypsin-like activity in vitro and suppresses breast cancer cell growth.