DNA methylation-based subclassification of psoriasis in the Chinese Han population
作者机构：Institute of DermatologyThe First Affiliated HospitalAnhui Medical UniversityHefei 230032China Department of DermatologyThe Second Affiliated HospitalAnhui Medical UniversityHefei 230601China Department of BiochemistryUniversity of New MexicoAlbuquerqueNM 87131USA The Key Laboratory of Dermatology (Anhui Medical University)Ministry of EducationHefei 230032China Collaborative Innovation Center for Complex and Severe DermatosisAnhui Medical UniversityHefei 230032China Department of DermatologyChina-Japan Friendship HospitalBeijing 100029China Graduate SchoolPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of DermatologyThe First Affiliated HospitalAnkui Medical UniversityHefei 230032China Molecular and Integrative Physiological SciencesHarvard T.H.CHAN School of PubIic HealthBostonMA 02115USA Hebrew SeniorLife Institute for Aging Research and Harvard Medical SchoolBostonMA 02131USA Broad Institute of MIT and HarvardCambridgeMA 02142USA
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2018年第12卷第6期
页 面：717-725页
核心收录：
基 金：mainly supported by the National Natural Science Foundation of China (No.81502713) Grants for Scientific Research of BSKY (No.XJ201634) Anhui Medical University,and Key Program of Outstanding Talents of Anhui Province (No.gxyqZD2017028).
主 题：psoriasis DNA methylation subclassification
摘 要：Psoriasis (Ps) is an inflammatory skin disease caused by genetic and environmental factors. Previous studies on DNA methylation (DNAm) found genetic markers that are closely associated with Ps, and evidence has shown that DNAm mediates genetic risk in Ps. In this study, Consensus Clustering was used to analyze DNAm data, and 114 Ps patients were divided into three subclassifications. Investigation of the clinical characteristics and copy number variations (CNVs) of , , and in the three subclassifications revealed no significant differences in gender ratio and in Ps area and severity index (PASI) score. The proportion of late-onset (≥40 years) Ps patients was significantly higher in type I than in types II and III ( = 0.035). Type III contained the smallest proportion of smokers and the largest proportion of non-smoking Ps patients ( = 0.086). The CNVs of and showed no significant differences but the CNV of significantly differed among the three subclassifications ( = 0.044). This study is the first to profile Ps subclassifications based on DNAm data in the Chinese Han population. These results are useful in the treatment and management of Ps from the molecular and genetic perspectives.
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