Reversible Histone H2B Monoubiquitination Fine-Tunes Abscisic Acid Signaling and Drought Response in Rice
作者机构：National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070 China BPMP CNRS INRA Montpellier SupAgro Universite de Montpellier 34060 Montpellier France Present address: Tobacco Research Institute of Chinese Academy of Agricultural Sciences Qingdao 266101 China Present address: Department of Biology University of Pennsylvania Philadelphia PA 19104 USA
出 版 物：《Molecular Plant》 (分子植物（英文版）)
年 卷 期：2019年第12卷第2期
页 面：263-277页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 09[农学]
基 金：国家自然科学基金 国家科技攻关计划项目 the Fundamental Research Funds for the Central Universities
主 题：ABA signaling transcriptional regulation chromatin remodeling histone monoubiquitination rice
摘 要：Histone H2B monoubiquitination (H2Bub1) plays important roles in several physiological and developmental processes, but its roles in the regulation of plant stress responses remain elusive. Here, we report that H2Bub1 is crucially involved in abscisic acid (ABA) signaling and drought response in rice. We found that rice HISTONE MONOUBIQUITINATION2 (OsHUB2), an E3 ligase for H2Bub1, in teracted with OsbZIP46, a key transcription factor regulating ABA signaling and drought response in rice. Genetic analyses suggest that OsHUB2, upregulated by drought and ABA, positively modulates ABA sensitivity and drought resistance. The H2Bub1 levels were in creased in the target genes of OsbZIP46 under the drought stress and ABA treat- merits, which were positively correlated with their increased expression levels. Interestingly, MODD, a reported suppressor of ABA signaling and drought resistance by mediating OsbZIP46 deactivation and degradation, could reduce the H2Bub1 levels in the target genes of OsbZIP46 by recruiting a putative deubiquitinase OsOTLD1 . Suppression of OsOTLD1in vivo resulted in increased H2Bub1 levels and expression of OsbZIP46 target genes. Collectively, these fin dings established an elaborate mecha nism of histone monoubiquitination in the fine-turning of ABA signaling and drought response by balancing H2Bub1 deposition and removal.
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