The Effect of Hypoxia on Expression of Basic Fibroblast Growth Factor in Pulmonary Vascular Pericytes

作     者：王林 熊密 车东媛 刘绍春 郝春荣 郑晓静 WANG Lin,XIONG Mi, CHE Dongyuan, LIU Shaochun, HAO Chunrong (Department of Pathology, School of Basic Medical Sciences,Tongji Medical University, Wuhan 430030) ZHENG Xiaojing (Department of Nephrology, Tongji Hospital, Tongji Medical University, Wuhan 4

作者机构：Department of Pathology School of Basic Medical Sciences Tongji Medical University Wuhan Department of Nephrology Tongji Hospital Tongji Medical University Wuhan 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2000年第20卷第4期

页      面：265-267页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：This project was supported by the grant of the NationalNature Sciences Foundation of China (No. 39570289) 

主　　题：hypoxia basic fibroblast growth factor pulmonary hypertension pericytes 

摘      要：To examine whether hypoxia exerts effect on the expression of basic fibroblast growth ac- tor (bFGF) in pulmonary vascular pericytes (PC), cell culture, in .citu hybridization with probe of digoxigenin-11-dUTP-labled cDNA, immunocytochemistry and image analysis were employed in this study. The results showed that the expression amount of bFGF mRNA and protein in PC of hypoxia (H) group was 1.31 times (P0. 01) and 1. 17 times (P0. 01) that of normoxia (N) group re- spectively. It suggests that hypoxia can directly enhance the expression of bFGF mRNA and protein in PC. Increased expression of bFGF may play an important role in the process of PC proliferation and differentiation of PC into smooth muscle-like cells.