Synthesis of Optically Active β-Alkyl-α-methylene-γ-butyro- lactones from Enantioselective Biotransformation of Nitriles, an Unusual Inversion of Enantioselectivity

作     者：赵生敏 王梅祥 

作者机构：Center for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2002年第20卷第11期

页      面：1291-1299,1129页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：theMajorStateBasicResearchDevelopmentProgram (No.2 0 0 0 0 775 0 6 )  andtheNationalNaturalScienceFoundationofChina (No .2 0 0 0 32 0 2 0 )andChineseAcademyofSciences 

主　　题：biotransformation nitrile hydratase amidase optically active β-alkyl-α-methylene-γ-butyrolactone inversion of enantioselectivity 

摘      要：A new approach to optically active β-alkyl-α-methylene-γ-butyrolactone derivatives was reported from the Rhodococcus sp. AJ270-catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has been observed when a methyl protection was introduced into the hydroxy group of the parent substrate.