Application of Variance Component Analysis (ANOVA) in Setup Errors and PTV Margins for Lung Cancer with Stereotactic Body Radiation Therapy (SBRT)
Application of Variance Component Analysis (ANOVA) in Setup Errors and PTV Margins for Lung Cancer with Stereotactic Body Radiation Therapy (SBRT)作者机构：School of Physics and Technology Wuhan University Wuhan China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan China
出 版 物：《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 (医学物理学、临床工程、放射肿瘤学（英文）)
年 卷 期：2018年第7卷第4期
页 面：522-538页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：SBRT KV-CBCT PTV Margin Setup Errors DVH
摘 要：Purpose: To investigate the feasibility of applying ANOVA newly proposed by Yukinori to verify the setup errors, PTV (Planning Target Volume) margins, DVH for lung cancer with SBRT. Methods: 20 patients receiving SBRT to 50 Gy in 5 fractions with a Varian iX linear acceleration were selected. Each patient was scanned with kV-CBCT before the daily treatment to verify the setup position. Two other error calculation methods raised by Van Herk and Remeijer were also compared to discover the statistical difference in systematic errors (Σ), random errors (σ), PTV margins and DVH. Results: Utilizing two PTV margin calculation formulas (Stroom, Van Herk), PTV calculated by Yukinori method in three directions were (5.89 and 3.95), (5.54 and 3.55), (3.24 and 0.78) mm;Van Herk method were (6.10 and 4.25), (5.73 and 3.83), (3.51 and 1.13) mm;Remeijer method were (6.39 and 4.57), (5.98 and 4.10), (3.69 and 1.33) mm. The volumes of PTV using Yukinori method were significantly smaller (P 0.05) among three methods. Conclusions: In lung SBRT treatment, due to fraction reduction and high level of dose per fraction, ANOVA was able to offset the effect of random factors in systematic errors, reducing the PTV margins and volumes. However, no distinct dose distribution improvement was founded in target volume and organs at risk.
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