Liposome-C-erbB_2 antisense oligodoxynucleotides in human ovarian cancer cells
脂质体—C-erbB_2反义寡核苷酸对卵巢癌细胞的作用(英文)作者机构：上海医科大学妇产科医院上海200011 中国科学院上海细胞生物学研究所上海200031
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2001年第114卷第7期
页 面：63-65,107-108页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：ThisworkwassupportedbytheNationalNaturalScienceFoundationof China (No 39470 72 4)
主 题：proto oncogene · oligodeoxynucleotides · antisense · ovarian neoplasms
摘 要：Objective To explore the effects of liposome C erbB 2 antisense phosphorothioate oligodeoxynucleotides (S ODNs) on C erbB 2 proto oncogene expression and cell proliferation in human ovarian cancer cells Methods The effects of liposome C erbB 2 S ODNs on C erbB 2 protein expression, cell cycle and cell proliferation in human ovarian cancer cells were studied by means of flow cytometry and 3H thymidine incorporation Results Liposome C erbB 2 S ODNs can specifically reduce C erbB 2 protein expression in human ovarian cancer cells, accompanied by a 30% inhibition of cell proliferation The effectiveness of liposome C erbB 2 S ODNs on the expression of C erbB 2 was about 40 times higher than that of C erbB 2 S ODNs Conclusions The data suggest that antisense therapy might be a useful method of gene therapy in ovarian cancer The effectiveness of C erbB 2 S ODNs could be greatly increased by adsorption of S ODNs by liposomes
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