利妥昔单抗成功治疗MuSK抗体阳性重症肌无力患者
Successful treatment of MuSK antibody-positive myasthenia gravis with rituximab作者机构：Department of Neurology Martin Luther University of Halle- Wittenberg Ernst- Grube- Strasse 40 06120 Hal- le/SaaleGermany Dr.
出 版 物：《世界核心医学期刊文摘(神经病学分册)》 (Digest of the World Core Medical Journals.Clinical Neurology)
年 卷 期：2006年第8期
页 面：34-34页
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
主 题：重症肌无力 单抗 神经肌肉疾病 利妥昔 抗体阳性 MuSK 患者
摘 要：We report on a 56- year- old woman with muscle- specific receptor tyrosine kinase (MuSK) antibody- positive myasthenia with predominant bulbar symptoms and respiratory insufficiency. Conventional immunosuppression (predniso- lone, azathioprine, mycophenolate mofetil) could not maintain the clinical improvement initially achieved by repeated plasma exchanges. Therefore, treatment with rituximab was initiated. After 2 months of rituximab treatment, remarkable clinical improvement correlating with a reduction of MuSK serum antibodies was seen. The patient continued to remain stable 12 months after initiation of therapy. This case report demonstrates that rituximab may be an effective and tolerable treatment in MuSK antibody- positive myasthenia gravis.
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