Vascular smooth muscle cell differentiation－2010

作     者：Joseph M.Miano 

作者机构：Aab Cardiovascular Research InstituteUniversity of Rochester School of Medicine & DentistryRochesterNew York 14642USA 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2010年第24卷第3期

页      面：169-180页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：VSMC gene Vascular smooth muscle cell differentiation cell 

摘      要：Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene *** cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which,in turn,orchestrate the activation of contractile genes collectively defining this cell *** discovery of myocardin and its close association with serum response factor has represented a major break-through for the molecular understanding of vascular smooth muscle cell *** have been shown to improve the outcome of vessel wall remodeling following injury and have provided further insights into the molecular circuitry that defines the vascular smooth muscle cell *** review summarizes the progress to date in each of these areas of vascular smooth muscle cell biology.