Treatment of established colon carcinoma-bearing mice by dendritic cells pulsed with lysates of heat-treated tumor cells

作     者：YING MinGang1,ZHEN QiuHong2,LIU Sheng1,GONG FuSheng2 & XIE YunQing2 1 Abdominal Surgery,Fujian Provincial Tumor Hospital,Teaching Hospital of Fujian Medical University,Fuzhou 350014,China 2 Surgical Laboratory,Fujian Provincial Tumor Hospital,Teaching Hospital of Fujian Medical University,Fuzhou 350014,China 

作者机构：Abdominal Surgery Fujian Provincial Tumor Hospital Teaching Hospital of Fujian Medical University Fuzhou 350014 China Surgical Laboratory Fujian Provincial Tumor Hospital Teaching Hospital of Fujian Medical University Fuzhou 350014 China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2009年第52卷第9期

页      面：831-835页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Key Project of Fujian Provincial Scientific Program (Grant No. 2007Y0014) 

主　　题：dendritic cell heat treatment colon carcinoma 

摘      要：To investigate the therapeutic effect of dendritic cells pulsed with lysates of heat-treated CT26 colon carcinoma cells. Bone marrow-derived DCs were pulsed with lysates of heat-treated tumor cells and were used to immunize BALB/c mice with established colon carcinoma. Cytotoxic T lymphocyte (CTL) response was detected. The therapeutic effect induced by DCs was observed by tumor weight and survival time. DCs pulsed with lysates of heat-treated tumor cells markedly induced specific cytotoxic activity of CTLs. Tumor growth in the immunized BALB/c mice was significantly inhibited and the survival time of the tumor-bearing mice was prolonged. DCs pulsed with lysates of heat-treated tumor cells have an observable therapeutic effect on established colon carcinoma-bearing mice.