Wg signaling in Drosophila heart development as a pioneering model

作     者：Xiushan Wu The Center for Heart Development, Key Lab of MOE for Developmental Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, China 

作者机构：The Center for Heart Development Key Lab of MOE for Developmental Biology and Protein Chemistry College of Life Sciences Hunan Normal University Changsha 410081 China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2010年第37卷第9期

页      面：593-603页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071008[理学-发育生物学] 

基　　金：supported in part by the National Basic Research Program of China (No.2005CB522505) the National Natural Science Foundation of China (No.30930054) 

主　　题：heart development Wg/Wnt signaling pioneering model congenital malformations 

摘      要：The heart is one of the first functional embryonic organs occurring during development. The fundamental developmental processes and genes involved in cardiogenesis are conserved between the invertebrates and vertebrates. In the past fifteen years, one of signaling pathways that has been best characterized in heart development in both invertebrates and vertebrates is the Wg/Wnt signaling pathways. Since our discovery of the Wg signaling required for the early heart development in Drosophila, the past fifteen years have witnessed tremendous progress in the understanding of specific Wnt signaling pathways in vertebrate cardiogenesis. This review will summarize the current state of knowledge of Wg signaling transduction in Drosophila heart development, which will benefit our understanding of vertebrate cardiogenesis and human congenital malformations.