Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese

作     者：LING-LING XU HONG-DING XIANG CHANG-CHUN QIU QUN XU 

作者机构：Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China National Laboratory of Medical Molecular Biology School of Basic Medicine Peking Union Medical College Institute of Basic Medical Science Chinese Academy of Medical Science Beijing 100005 China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2008年第21卷第3期

页      面：188-192页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was supported by the Capital Development Fund Project (Grant No. 2002-1017) 

主　　题：Ghrelin Polymorphism Metabolic syndrome the Han Nationality 

摘      要：Objective To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. Methods A total of 240 patients with metabolic syndrome and 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism analysis. Results The allelic frequency of the Leu72Met polymorphism was 17.3% in the patient group and 11.9% in the control group （x^2=7.36, P=0.007）. Metabolic syndrome was more prevalent among carriers of the Met72 variant （43.8 vs 33.1%, age- and sex-adjusted odds ratio=1.57, P=0.01）. No Arg51Gln variants were found in our study subjects. Conclusion Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Han Nationality Chinese.