Manifestations of gastrointestinal plasmablastic lymphoma: A case series with literature review
Manifestations of gastrointestinal plasmablastic lymphoma: A case series with literature review作者机构：Department of Pathology University of South Florida Morsani College of Medicine Tampa FL 33612 United States. Department of Pathology Wayne State University School of Medicine Detroit MI 48202 United States Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 United States Department of Surgical Pathology H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 United States Department of Hematopathology and Laboratory Medicine H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第33期
页 面：11894-11903页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Plasmablastic lymphoma Undifferentiated carcinoma Non-Hodgkin lymphoma Diverse clinical manifestation and treatment
摘 要：Plasmablastic lymphoma (PBL) rarely occurs in the gastrointestinal (GI) tract with limited studies reported. We reviewed the clinical histories and pathology of four patients with GI PBL at our institute and similar case reports published in peer-reviewed journals. In our first case, a 40 year-old human immunodeficiency virus positive male presented with a hemorrhoid-like sensation, and was diagnosed with PBL via biopsy of a rectal mass. The second case involves a 65 year-old healthy male with bloody diarrhea who was found to have PBL in a resected sigmoid mass. The third patient was a 41 year-old male with a history of Crohn’s disease who presented with abdominal pain, diarrhea, and weight loss. A small intestinal mass (PBL) was removed. The fourth patient was a 65-year-old male who was found PBL after surgical resection of bowel for his florid Crohn’s disease. He later developed secondary acute myeloid leukemia. Clinical outcome was very poor in 3 out of 4 patients as reported in the literature. One patient survived chemotherapy followed by autologous transplant. The prototypical clinical presentation and variations of PBL can help create a more comprehensive differential diagnosis for GI tumors and establish an appropriate therapeutic guideline.
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