Towards reperfusion-centric preclinical stroke research:outside the box of “reperfusion injury”

作     者：Chia Yi Kuan Yu Yo Sun 

作者机构：Department of PediatricsChildren’s Healthcare of AtlantaDivision of Neurologyand the Center for Neurodegenerative Diseases (CND)The Emory University School of Medicine Department of PediatricsChildren’s Healthcare of AtlantaDivision of NeurologyThe Emory University School of Medicine 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第4期

页      面：534-536页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the NIH grant NS084744 to YK 

主　　题：Towards reperfusion-centric preclinical stroke research PA reperfusion injury MCAO 

摘      要：Stroke is a major health issue of increasing significance for any society with an aging population. Globally, stroke is the second-leading cause of death with approximately 5.9 million fatal events in 2010, equivalent to 11.1% of all deaths. Yet, despite years of preclinical research on neuroprotection and a multitude of clinical trials, tissue plas- minogen activator （tPA）-mediated recanalization remains the mainstay of acute ischemic stroke therapy, whereas tPA thrombolysis rarely provides benefits in the mechanical occlusion-based stroke models. This split between the bench and bedside raised the concern over the clinical ap- plicability of neuroprotection in acute ischemic stroke. In this perspective commentary, we call for attention to the differences between mechanical-occlusion and thrombo- embolic stroke models in cerebral hemodynamics （Figure 1A, B）, the implications of these differences in view of progressive pathobiology of ischemic stroke （Figure 1C）, and the need and strategies towards reperfusion-centric preclinical stroke research.