Research on Arterial Stiffness Status in Type 2 Diabetic Patients Based on Pulse Waveform Characteristics

作     者：Gaoyang Li Xiaorui Song Aike Qiao Makoto Ohta 

作者机构：Graduate School of Biomedical EngineeringTohoku UniversitySendaiMiyagiJapan. Department of RadiologyTaishan Medical UniversityNo.619 Greatwall RoadDaiyue DistrictTaianShandong271000China College of Life Science and BioengineeringBeijing University of TechnologyNo.100PingleyuanChaoyang DistrictBeijing100022China Institute of Fluid ScienceTohoku UniversitySendai980-8577MiyagiJapan ELyTMaX UMI 3757CNRS-Universitéde Lyon-Tohoku UniversityJapan 

出 版 物：《Computer Modeling in Engineering & Sciences》 (工程与科学中的计算机建模（英文）)

年 卷 期：2018年第117卷第11期

页      面：143-155页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Fostering Joint International Research, (15KK0197) Division of Integrative Organismal Systems, IOS Marlow Industries Analog Devices Japan Agency for Medical Research and Development, AMED, (18he1802004h0002) International Spinal Research Trust Japan Society for the Promotion of Science, JSPS, (16H01805) Japan Science and Technology Agency, JST Stichting HPCN Program on Open Innovation Platform with Enterprises, Research Institute and Academia, OPERA 

主　　题：Type 2 diabetes pulse waveform arterial stiffness. 

摘      要：For patients with type 2 diabetes,the evaluation of pulse waveform characteristics is helpful to understand changes in arterial ***,there is a lack of comprehensive analysis of pulse waveform ***,we aimed to investigate the changes in pulse waveform characteristics in patients with type 2 diabetes due to increased arterial *** this study,25 patients with type 2 diabetes and 50 healthy subjects were selected based on their clinical ***,height,weight,blood pressure,and pulse pressure were collected as the subjects’basic *** brachial-ankle pulse wave velocity(baPWV)was collected as an index of arterial *** of time[the pulse wave period(T),the relative positions of peak point(T1)and notch point(T2),and pulse wave time difference between upper and lower limbs(T3)]and area[the total waveform area(A),and the areas of the waveform before(A1)and after(A2)the notch point]were extracted from the pulse wave signals as pulse waveform *** independent sample t-test was performed to determine whether there were significant differences between ***’s correlation analysis was performed to determine the correlations between pulse waveform parameters and *** were significant differences in T3,A,A1,and A2 between the groups(p0.05).For patients with type 2 diabetes,there were statistically significant correlations between baPWV and T3,A,A1,and A2(p0.05).This study quantitatively assessed changes in arterial pulse waveform parameters in patients with type 2 *** was demonstrated that pulse waveform characteristics(T3,A,A1,and A2)could be used as indices of arterial stiffness in patients with type 2 diabetes.