Osteogenesis of Adipose-Derived Stem Cells

作     者：Brian E. Grottkau Yunfeng Lin 

作者机构：Department of Orthopaedic SurgeryMassGeneral Hospital for Children and the Pediatric Orthopaedic Laboratory for Tissue Engineering and Regenerative MedicineHarvard Medical SchoolBostonMassachusettsUSA 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2013年第1卷第2期

页      面：133-145页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：funded by National Natural Science Foundation of China (81071273,31170929) Foundation for the Author of National Excellent Doctoral Dissertation of China (FANEDD 200977) Innovative Research Team of Education Department of Sichuan Province (13TD0038) 

主　　题：adipose derived stem cells osteogenesis bone tissue engineering osteogenic differentiation 

摘      要：Current treatment options for skeletal repair, including immobilization, rigid fixation, alloplastic materials and bone grafts, have significant limitations. Bone tissue engineering offers a promising method for the repair of bone deficieny caused by fractures, bone loss and tumors. The use of adipose derived stem cells （ASCs） has received attention because of the self-renewal ability, high proliferative capacity and potential of osteogenic differentiation in vitro and in vivo studies of bone regeneration. Although cell therapies using ASCs are widely promising in various clinical fields, no large human clinical trials exist for bone tissue engineering. The aim of this review is to introduce how they are harvested, examine the characterization of ASCs, to review the mechanisms of osteogenic differentiation, to analyze the effect of mechanical and chemical stimuli on ASC osteodifferentiation, to summarize the current knowledge about usage of ASC in vivo studies and clinical trials, and finally to conclude with a general summary of the field and comments on its future direction.