Chinese consensus on management of tyrosine kinase inhibitor-associated side effects in gastrointestinal stromal tumors

作     者：Jian Li Ming Wang Bo Zhang Xin Wu Tian-Long Lin Xiu-Feng Liu Ye Zhou Xin-Hua Zhang Hao Xu Li-Jing Shen Jing Zou Ping Lu Dong Zhang Wei-Jun Gu Mei-Xia Zhang Jian Pan Hui Cao 无 

作者机构：Department of Gastrointestinal OncologyKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of RespirologyRen Ji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200240China Department of DermatologyRen Ji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200240China Department of NephrologyThe General Hospital of the People’s Liberation ArmyBeijing 100853China Department of EndocrinologyThe General Hospital of the People’s Liberation ArmyBeijing 100853China Department of OphthalmologyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina Chinese Society of Surgeons for Gastrointestinal Stromal Tumor of the Chinese Medical Doctor Association Department of Gastrointestinal SurgeryReiji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China Department of Gastrointestinal SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of General Surgerythe General Hospital of the People’s Liberation ArmyBeijing 100853China Department of OncologyThe Chinese People’s Liberation Army 81^st HospitalNanjing 210031Jiangsu ProvinceChina Department of Gastric SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Department of Gastrointestinal SurgeryThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of General SurgeryThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 320100Jiangsu ProvinceChina Department of HematologyRen Ji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200240China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2018年第24卷第46期

页      面：5189-5202页

核心收录：

学科分类：10[医学] 

主　　题：Side effects Gastrointestinal stromal tumor Tyrosine kinase inhibitors Consensus guideline China 

摘      要：Tyrosine kinase inhibitors(TKIs) have improved the overall survival of patients with gastrointestinal stromal tumors(GISTs), but their side effects can impact dose intensity and, consequently, the clinical benefit. To date, no guideline or consensus has been published on the TKI-associated adverse reactions. Therefore, the Chinese Society of Surgeons for Gastrointestinal Stromal Tumor of the Chinese Medical Doctor Association organized an expert panel discussion involving representatives from gastrointestinal surgery, medical oncology, cardiology, dermatology, nephrology, endocrinology, and ophthalmology to consider the systemic clinical symptoms, molecular and cellular mechanisms, and treatment recommendations of GISTs. Here, we present the resultant evidence-and experience-based consensus to guide the management of TKI-associated side events in clinical practice.