Inhibitory effects of Curcuma aromatica oil on proliferation of hepatoma in mice

作     者：Wan Yin Wu Qin Xu Ling Chun Shi Wei Bin Zhang 

作者机构：Department of Cancerthe Second Affiliated Hospital of Guangzhou University of TCMGuangzhou 510120Guangdong ProvinceChina Department of PathologyGuangzhou University of TCMGuangzhou 510405Guangdong ProvinceChina Department of Pathologythe Second Affiliated Hospital of Guangzhou University of TCMGuangzhou 510120Guangdong ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2000年第6卷第2期

页      面：216-219页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National key project of the 9~(th) 5-year Plan for Medicine and Health,No.96-906-07-04 Guangdong provincial natural scientific grants,No.980663 

主　　题：Curcuma aromatica oil liver neoplasms cell proliferation mice 

摘      要：AIM To reveal the inhibitory effects ofCurcuma aromatica oil(CAO)on cellproliferation of hepatoma in *** Two tumor inhibitory experimentsof CAO on hepatoma in mice were *** inhibitory effects of CAO on proliferation ofhepatoma in mice were evaluated by DNA imagecytometry and immunohistochemical staining ofproliferating cell nuclear antigen(PCNA).RESULTS The tumor inhibitory rates of CAOwere 52% and 51% in two experiments,*** with those of the saline-treated control groups,both differences werestatistically significant(P0.01).In the groupof mice treated with CAO,the cellular nuclearDNA OD value(249±70),areas(623 μm^2±228 μm^2)and DNA(2.38±0.67)index of hepaticcarcinomas were significantly lower than thoseof the control group(430±160,1073 μm^2±101 μm^2 and 4.48±0.71).CAO also couldincrease diploidy cell rates(29.00%±9.34% vs2.97%±5.69%,P0.01)and decreasepentaploidy cell exceeding rate(30.04%±15.10% vs 70.89%±14.94%,P0.01).In thegroup of mice treated with CAO,the labelingindexes of proliferating cell nuclear antigen (PCNA-LI)were 30%±4%,which weresignificantly lower than 40%±6% of the controlgroup(P0.01).CONCLUSION The inhibition of CAO on thegrowth of hepatoma in mice might be associatedwith its depression on cellular proliferativeactivity.