Opioid system in L-DOPA-induced dyskinesia
作者机构：Transgenics SectionLaboratory of NeurogeneticsNational Institute on AgingNational Institutes of HealthBuilding 35Room 1A112MSC 370735 Convent DriveBethesdaMD 20892-3707USA
出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)
年 卷 期：2017年第6卷第1期
页 面：1-5页
核心收录：
基 金：This review was supported by the intramural research programs of National Institute on Aging(HC AG000928)
主 题：opioid endogenous system
摘 要：L-3,4-Dihydroxyphenylalanine(L-DOPA)-induced dyskinesia(LID)is a major clinical complication in the treatment of Parkinson’s disease(PD).This debilitating side effect likely reflects aberrant compensatory responses for a combination of dopaminergic neuron denervation and repeated L-DOPA *** endogenous opioid signal transduction pathways in basal ganglia have been well documented in *** receptors have been targeted to alleviate the ***,the exact role of this altered opioid activity is remains under active *** the present review,we discuss the current understanding of opioid signal transduction in the basal ganglia and how the malfunction of opioid signaling contributes to the pathophysiology of *** study of the opioid system in LID may lead to new therapeutic targets and improved treatment of PD patients.
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