Effects of Nitrobenzene on Liver Antioxidant Defense System of Carassius auratus

作     者：SHAO Peng YUAN Xing LIU Rui CAO Jian-ping 

作者机构：College of Urban and Environmental Science Northeast Normal University Changchun 130024 P. R. China Research Institute of Environment Yangtze Delta Institute of Tsinghua University Jiaxing 314006 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2010年第26卷第2期

页      面：204-209页

核心收录：

学科分类：090801[农学-水产养殖] 0908[农学-水产] 07[理学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

基　　金：Supported by the National Key Technologies Research & Development Program of China(No.2006BAC02A16-2) the Science and Technology Department Major Programs Project of Jilin Province,China(No.20065021) 

主　　题：Nitrobenzene Superoxide dismutase Catalase Glutathione S-transferase Malondialdehyde 

摘      要：With superoxidedismutase（SOD）, catalase（CAT）, glutathione S-transferase（GST） and malondialdehyde （MDA） as characteristic indexes, the effects of nitrobenzene（NB） on the liver antioxidant defense system of Carassius auratus were studied under the indoors stimulant conditions, and the toxic mechanisms were discussed. The exposure concentrations of NB were 0.5, 1.0, 5.0 and 10.0 mg/L, and the exposure time was 5, 10 and 15 days, respectively. The results show that the stress responses of four antioxidant indexes in the fish liver to nitrobenzene were different. The SOD activity was firstly inhibited and then induced. The CAT and GST activities were mainly induced. The MDA content in the high concentration group showed a significant time-effect relationship. In addition, the changes of CAT and SOD activities were not synchronous, and GST played an important part in the detoxification process of nitrobenzene.