Polymorphisms in the promoter region of IL10 gene are associated with virus etiology of infant bronchiolitis

作     者：Annukka Holster Johanna Terasjarvi Juho Vuononvirta Petri Koponen Ville Peltola Merja Helminen Qiushui He Matti Korppi Kirsi Nuolivirta 

作者机构：Seinajoki Central HospitalHanneksenrinne 760220 SeinajokiFinland Department of Medical Microbiology and ImmunologyTurku UniversityTurkuFinland Tampere Center forChild Health ResearchTampere University andU niversity HospitalTampereFinland Department of Pediatrics and Adolescent MedicineTurku University Hospital and Child and Youth Research InstituteUniversity of T urkuTurkuFinland Department of Medical MicrobiologyCapital Medical UniversityBeijingChina 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2018年第14卷第6期

页      面：594-600页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by the Tampere Tuberculosis Foundation(authors KN and MK) 

主　　题：Bronchiolitis IL10 gene polymorphism Infant Respiratory syncytial virus 

摘      要：Background Bronchiolitis is the most common infection leading to hospitalization in infancy. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and in our previous study, IL10 gene rs1800896 (-1082A/G) polymorphism was associated with viral etiology of infant bronchiolitis. The objective of this study was to evaluate the associations between IL10 single nucleotide polymorphisms (SNPs) at rs1800890 (-3575A/T), rs1800871 (-819C/T) or rs1800872 (-592C/A) either alone or combined with the SNP at rs1800896 (-1082G/A), and the etiology and severity of infant bronchiolitis. Methods Data on four IL10 SNPs were available from 135 full-term infants, hospitalized for bronchiolitis at age less than 6 months, and from 378 to 400 controls. Viral etiology was studied, and oxygen support, feeding support and the length of stay in hospital were recorded during bronchiolitis hospitalization. Results Infants with rhinovirus bronchiolitis had the IL10 rs1800890 variant AT or TT genotype less often (18.2%) than controls (63.3%, P=0.03), and likewise, had the IL10 rs1800896 variant AG or GG genotype less often (27.3%) than con-trols (65.5%, P=0.009). Twenty-eight infants with bronchiolitis had the variant–variant Grs1800896Trs1800890 haplotype, and none of them had rhinovirus infection. The IL10 rs1800871 or rs1800872 genotypes showed no associations with viruses. No association was found between any genotypes and bronchiolitis severity measures. Conclusion IL10 rs1800890 and rs1800896 polymorphisms differed between infants with rhinovirus bronchiolitis and con-trols, but not between infants with respiratory syncytial virus bronchiolitis and controls.