Effect of aging on stem cells
Effect of aging on stem cells作者机构：Regenerative Medicine UnitDepartment of MedicineLoma Linda University School of Medicine Musculoskeletal Disease CenterJerry L.Pettis Memorial VA Medical Center
出 版 物：《World Journal of Experimental Medicine》 (世界实验医学杂志)
年 卷 期：2017年第7卷第1期
页 面：1-10页
学科分类：10[医学]
主 题：Aging Biological aging Cellular aging Adult stem cells Premature aging Mesenchymal stem cell Stem cell renewal Tissue regeneration
摘 要：Pluripotent stem cells have the remarkable self-renewal ability and are capable of differentiating into multiple diverse cells. There is increasing evidence that the aging process can have adverse effects on stem cells. As stem cells age, their renewal ability deteriorates and their ability to differentiate into the various cell types is altered. Accordingly, it is suggested aging-induced deterioration of stem cell functions may play a key role in the pathophysiology of the various aging-associated disorders. Understanding the role of the aging process in deterioration of stem cell function is crucial, not only in understanding the pathophysiology of agingassociated disorders, but also in future development of novel effective stem cell-based therapies to treat agingassociated diseases. This review article first focuses on the basis of the various aging disease-related stem cell dysfunction. It then addresses the several concepts on the potential mechanism that causes aging-related stem cell dysfunction. It also briefly discusses the current potential therapies under development for aging-associated stem cell defects.
维普期刊数据库