Expression and Significance of Cyclooxygenase-2 in Human Pancreatic Carcinomas

作     者：王海霞 陈其奎 贾柳萍 王莉 Wang Haixia;CHEN Qikui;JIA Liuping;WANG Li

作者机构：广东省南海市人民医院消化内科528000 

出 版 物：《The Chinese-German Journal of Clinical Oncology》 (中德临床肿瘤学杂志（英文版）)

年 卷 期：2005年第4卷第2期

页      面：121-123页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：pancreatic neoplasms cyclooxygenase immunohistochemistry 

摘      要：The inhibition of cyclooxygenase-2 (COX-2) by nonstcroidal anti-inflammatorydrugs may prevent the occurrence and decrease the incidence of gastrointestinal malignant *** study was designed to detect the expression patterns of COX-2 in human normal, benign, andmalignant pancreatic tissues and investigate the correlation between the expression of COX-2 andBcl-2 in malignant pancreatic tissues, which may help to demonstrate the functional role of COX-2and Bcl-2 in pancreatic carcinogenesis and carcinoma development. Methods: Immunohistologicalanalysis of COX-2 and Bcl-2 was performed on different human pancreatic samples, including malignanttissues. The correlation between COX-2 and Bcl-2, as well as clinic-pathological characteristics ofpancreatic carcinoma was evaluated by statistic analysis. Results: COX-2 and Bcl-2 proteins weredetected in 22 of 30 (73.3%) and 20 of 30 (66.7%) malignant pancreatic tissues, which were higherthan those in normal and benign tissues (P 0.05). Conclusion: COX-2 protein is over-expressed in human malignantpancreatic tissues. The co-expression of COX-2 and Bcl-2 might play an important role in theregulation of apoptosis of pancreatic carcinoma cells.