Adipokines: Biomarkers for osteoarthritis?

作     者：Thitiya Poonpet Sittisak Honsawek 

作者机构：Department of Biochemistry and OrthopaedicsFaculty of MedicineChulalongkorn UniversityKing Chulalongkorn Memorial HospitalThai Red Cross SocietyPatumwanBangkok 10330Thailand 

出 版 物：《World Journal of Orthopedics》 (世界骨科杂志（英文版）)

年 卷 期：2014年第5卷第3期

页      面：319-327页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Supported by Post-Doctoral Fellowship Research Grant from Ratchadaphiseksomphot Endowment Fund Chulalongkorn University,Ratchadapiseksompotch Fund Faculty of Medicine,Chulalongkorn University,Thailand Research Fund the Commission of Higher Education 

主　　题：Osteoarthritis Adipokines Biomarker Obesity Adipose tissue 

摘      要：Osteoarthritis(OA)is one of the most common degenerative joint diseases in aging *** is an important risk factor for initiation and progression of *** is accepted that excess body weight may lead to cartilage degeneration by increasing the mechanical forces across weight-bearing ***,emerging data suggest that additional metabolic factors released mainly by white adipose tissue may also be responsible for the high prevalence of OA among obese ***-derived molecules‘‘adipokines’’have prompt much interest in OA pathophysiological research over the past decade since they play an important role in cartilage and bone ***,the aim of this review is to summarize the current knowledge on the role of adipokines including leptin,adiponectin,visfatin and resistin in OA and their potential to be used as biomarkers for earlier diagnosis,classifying disease severity,monitoring disease progression,and testing pharmacological interventions for *** OA patients,leptin,visfatin and resistin showed increased production whereas adiponectin showed decreased *** and adiponectin are far more studied than visfatin and ***,altered adipokine levels also contribute to a wide range of *** experiments are still crucial for understanding the relationship between adipokines and OA.