MicroRNAs in heart and circulation during physical exercise

作     者：Lijun Wang Yicheng Lv Guoping Li Junjie Xiao Lijun Wang;Yicheng Lv;Guoping Li;Junjie Xiao

作者机构：Cardiac Regeneration and Ageing LabInstitute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02215USA 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2018年第7卷第4期

页      面：433-441页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 

基　　金：supported by grants from the National Natural Science Foundation of China(81722008,91639101,and81570362 to JX and 81800358 to LW) the Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-09-E00042 to JX) the Science and TechnologyCommission of Shanghai Municipality(17010500100 to JX) the development fund for Shanghai talents(to JX) 

主　　题：物理 miRNAs 发行量 心血管 真核细胞 上海大学 训练 非编码 

摘      要：Exercise training is beneficial to the cardiovascular system. MicroRNAs(miRNAs, miRs) are a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of eukaryotic gene expression. Exercise training alters the expression levels of large amounts of miRNAs in the heart. In addition, circulating miRNAs appear to be regulated by exercise training. In this review, we will summarize recent advances in the regulation of miRNAs during physical exercise intervention in various cardiovascular diseases, including pathologic cardiac hypertrophy, myocardial fibrosis, ischemia-reperfusion injury, myocardial infarction, and heart failure. The regulatory role of circulating miRNAs after exercise training was also reviewed. In conclusion, miRNAs might be a valuable target for treatment of cardiovascular diseases and have great potential as biomarkers for assessment of physical performance.