Ikaros isoforms:The saga continues

作     者：Laura A Perez-Casellas Aleksandar Savic Sinisa Dovat 

作者机构：Department of PediatricsUniversity of Wisconsin-MadisonMadisonWI 53792United States Clinic of HematologyClinical Center of VojvodinaFaculty of MedicineUniversity in Novi SadNovi Sad 21000Serbia Department of PediatricsPennsylvania State UniversityCollege of MedicineH085Division of Pediatric Hematology/OncologyHersheyPA 17033-0850United States 

出 版 物：《World Journal of Biological Chemistry》 (世界生物化学杂志（英文版）（电子版）)

年 卷 期：2011年第2卷第6期

页      面：140-145页

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：Supported by (in part) An R01 HL095120 grant a St.Baldrick’s Foundation Career Development Award the Four Diamonds Fund of the Pennsylvania State University College of Medicine and the John Wawrynovic Leukemia Research Scholar Endowment (SD) 

主　　题：Ikaros Chromatin,Pericentromeric Transcription IK-H Leukemia γ satellite 

摘      要：Through alternate splicing,the Ikaros gene produces multiple *** is essential for normal hematopoiesis and possesses tumor suppressor *** isoforms interact to form dimers and potentially multimeric *** Ikaros complexes produced by the presence of different Ikaros isoforms are hypothesized to confer distinct *** dominantnegative Ikaros isoforms have been shown to inhibit the tumor suppressor activity of full-length ***,we describe how Ikaros activity is regulated by the coordinated expression of the largest Ikaros isoforms IK-1 and *** IK-1 is described as full-length Ikaros,IK-H is the longest Ikaros ***-H,which includes residues coded by exon 3B (60 bp that lie between exons 3 and 4),is abundant in human but not murine hematopoietic *** residues that lie within the 20 amino acids encoded by exon 3B give IK-H DNA-binding characteristics that are distinct from those of ***,IK-H can potentiate or inhibit the ability of IK-1 to bind ***-H binds to the regulatory regions of genes that are upregulated by Ikaros,but not genes that are repressed by *** IK-1 localizes to pericentromeric heterochromatin,IK-H can be found in both pericentromeric and non-pericentromeric ***-silencing activity of gamma satellite DNA has been shown to depend on the binding of IK-H,but not other Ikaros *** unique features of IK-H,its influence on Ikaros activity,and the lack of IK-H expression in mice suggest that Ikaros function in humans may be more complex and possibly distinct from that in mice.