Higher Viral Load and Prolonged Viral Shedding Period is Associated with Impaired Th17 Cell Response in Patients with H1N1 Influenza A

作     者：Gui-lin Yang Ying-xia Liu Mu-tong Fang Wei-long Liu Xin-chun Chen John Nunnari Jing-jing Xie Ming-feng Liao Ming-xia Zhang Guo-bao Li Pei-ze Zhang Yi Guan Bo-ping Zhou 

作者机构：Shenzhen Institute of HepatologyShenzhen Third People’s Hospital Department of Neurobiologythe University of Massachusetts Medical School State Key Laboratory of Emerging Infectious DiseasesLi Ka Shing Faculty of MedicineThe University of Hong KongFaculty of Medicine Building 

出 版 物：《国际感染病学（电子版）》 (Infection International(Electronic Edition))

年 卷 期：2012年第1卷第3期

页      面：137-145页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Viral load Viral shedding period H1N1 influenza A Th17 cells TGF-β 

摘      要：Objective To explore whether age,disease severity,cytokines and lymphocytes in H1N1 influenza A patients correlate with viral load and *** Total of 70 mild and 16 severe patients infected with H1N1 influenza A virus were enrolled in this *** It was found that the patients under 14 years old and severe patients displayed significantly higher viral loads and prolonged viral shedding periods compared with the patients over 14 years old and mild patients,respectively(P 0.05).Moreover,the patients under 14 years old and severe patients displayed significantly lower Th17 cell frequency than the patients over 14 years old and mild patients(P 0.01).The viral shedding period inversely correlated with the frequency of IL-17+IFN-γ-CD4+ T ***,the decreased concentration of serum TGF-β correlated with the decreased frequency of IL-17+IFN-γ-CD4+ T *** Both younger and severe patients are associated with higher viral loads and longer viral shedding periods,which may partially be attributed to the impaired Th17 cell response.