Prevalence of hepatitis C infection among intravenous drug users in Shanghai
Prevalence of hepatitis C infection among intravenous drug users in Shanghai作者机构：Microbiology LaboratoryCenter for Disease Control and Prevention of Xuhui Microbiology LaboratoryShanghai Public Health Clinical Center
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2013年第19卷第32期
页 面：5320-5325页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：Supported by Science and Technology Commission Xuhui District and Xuhui Health Bureau of Shanghai No.SHXH201226
主 题：Hepatitis C Anti-hepatitis C virus antibodies Prevalence of hepatitis C virus Active infection rate Intravenous drug users
摘 要：AIM:To characterize the prevalence of hepatitis C virus(HCV)infection among Chinese intravenous drug users(IDUs).METHODS:A total of 432 adult IDUs(95 women and337 men)in Shanghai were included in the *** third-generation Elecsys Anti-HCV assay(Roche Diagnostics GmbH,Sandhofer Strasse 116,D-68305,Mannheim,Germany)was used to screen for antibodies against *** RIBA strip,a supplemental antiHCV test with high specificity,was performed on all of the samples that tested positive during the initial *** of the anti-HCV positive samples were analyzed with a Cobas TaqMan 48 Analyzer(Roche Diagnostics)for direct detection of HCV *** of the HCV RNA-positive samples were sequenced for genotype ***:The preliminary screening identified 262(60.6%)subjects who were seropositive for *** the 62 females and 200 males seropositive subjects,16(16.7%)and 65(19.3%),respectively,were confirmed by RIBA,yielding an overall HCV seropositive rate of18.8%.Four female(6.5%)and 14 male(7.0%)subjects tested positive for HCV RNA,indicating an active infection rate of 4.2%for the entire study *** 18 HCV RNA-positive serum samples were *** individuals were genotype 1b,and four were genotype *** individual each was infected with genotypes 2a,2b and *** subjects were coinfected with multiple strains:two with genotypes 1a and 2a,and two with genotypes 1b and *** active infection rate among HCV-seropositive individuals was22.2%,which was significantly lower than most ***:The prevalence of HCV is relatively low among IDUs in Shanghai,with a spontaneous recovery rate much higher than previous estimates.
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