Selecting the best strategy of treatment in newly diagnosed advanced-stage ovarian cancer patients

作     者：Lucas Minig Cristina Zorrero Pablo Padilla Iserte Andres Poveda 

作者机构：Gynecology Department Clinical Area of Gynecologic Oncology Valencian Institue of Oncology Medical Oncology Department Clinical Area of Gynecologic Oncology Valencian Institue of Oncology 

出 版 物：《World Journal of Methodology》 (世界方法学杂志)

年 卷 期：2015年第5卷第4期

页      面：196-202页

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

主　　题：Ovarian cancer Advanced stage Primary debulking surgery Neoadjuvant chemotherapy Patients' selection 

摘      要：Although it is assumed that the combination of chemotherapy and radical surgery should be indicated in all newly diagnosed advanced-stage ovarian cancer patients, one of the main raised questions is how to select the best strategy of initial treatment in this group of patients, neoadjuvant chemotherapy followed by interval debulking surgery or primary debulking surgery followed by adjuvant chemotherapy. The selection criteria to offer one strategy over the other as well as a stepwise patient selection for initial treatment are described. Selecting the best strategy of treatment in newly diagnosed advanced stage ovarian cancer patients is a multifactorial and multidisciplinary decision. Several factors should be taken into consideration:(1) the disease factor, related to the extension and localization of the disease as well as tumor biology;(2) the patient factor, associated with patient age, poor performance status, and co-morbidities; and(3) institutional infrastructure factor, related to the lack of prolonged operative time, an appropriate surgical armamentarium, as well as well-equipped intensive care units with well-trained personnel.